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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IRS1 All Species: 20.91
Human Site: S503 Identified Species: 41.82
UniProt: P35568 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35568 NP_005535.1 1242 131591 S503 P G T G L G T S P A L A G D E
Chimpanzee Pan troglodytes XP_001134895 1241 131474 S503 P G T G L G T S P A L A G D E
Rhesus Macaque Macaca mulatta XP_001109882 1252 133053 S503 P G T G L G T S P A L A G D E
Dog Lupus familis XP_543274 1180 124676 N480 S S T L T A P N G H Y I L P R
Cat Felis silvestris
Mouse Mus musculus P35569 1233 130705 S498 P G A N L G T S P A L P G D E
Rat Rattus norvegicus P35570 1235 131160 S498 P G A T M G T S P A L T G D E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505439 368 40215
Chicken Gallus gallus NP_001026741 1240 131795 S501 P G T G L G T S P A L A G D E
Frog Xenopus laevis P84770 1088 119088 M403 H G S T S D C M C P R R S S A
Zebra Danio Brachydanio rerio XP_687702 1136 122765 P451 N Y I C M A K P G S L P G A G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9XTN2 968 107813 R283 S Q N S L E L R S C S S P H N
Honey Bee Apis mellifera XP_391985 1190 129451 C480 I S P A S G A C S T D S A G S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.5 87.5 N.A. 89.5 89.7 N.A. 26.4 91.2 59.9 52.2 N.A. 20.6 20.4 N.A. N.A.
Protein Similarity: 100 99.2 98 89.4 N.A. 92.3 92.2 N.A. 28 92.9 67.6 61.3 N.A. 37.6 37.3 N.A. N.A.
P-Site Identity: 100 100 100 6.6 N.A. 80 73.3 N.A. 0 100 6.6 13.3 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 13.3 N.A. 80 80 N.A. 0 100 13.3 26.6 N.A. 13.3 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 9 0 17 9 0 0 50 0 34 9 9 9 % A
% Cys: 0 0 0 9 0 0 9 9 9 9 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 0 0 0 0 9 0 0 50 0 % D
% Glu: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 50 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 59 0 34 0 59 0 0 17 0 0 0 59 9 9 % G
% His: 9 0 0 0 0 0 0 0 0 9 0 0 0 9 0 % H
% Ile: 9 0 9 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 9 50 0 9 0 0 0 59 0 9 0 0 % L
% Met: 0 0 0 0 17 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 9 0 9 9 0 0 0 9 0 0 0 0 0 0 9 % N
% Pro: 50 0 9 0 0 0 9 9 50 9 0 17 9 9 0 % P
% Gln: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 9 0 0 9 9 0 0 9 % R
% Ser: 17 17 9 9 17 0 0 50 17 9 9 17 9 9 9 % S
% Thr: 0 0 42 17 9 0 50 0 0 9 0 9 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _